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Sr. Director, Modeling - Structural Biology & Chemistry

Gilead Sciences

Gilead Sciences

Foster City, CA, USA
Posted on Tuesday, February 13, 2024

For Current Gilead Employees and Contractors:

Please log onto your Internal Career Site to apply for this job.

At Gilead, we’re creating a healthier world for all people. For more than 35 years, we’ve tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer – working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world’s biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference.


We empower our leaders to step up, share ideas, listen, learn, and lead. We’re welcoming bright, diverse, and imaginative minds; we’re nurturing them to foster an environment of inclusion and growth where innovation is encouraged. We expect our people leaders to model that environment, and to focus on creating inclusion, developing talent, and enabling teams.


Every member of Gilead’s team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we’re looking for the next wave of passionate and ambitious people ready to make a direct impact. Join Gilead and help create possible, together.


Job Description

As a Senior Director in the Modeling Group and a Senior Staff member of the Structural Biology and Chemistry Department, you will work with other Senior Staff members to formulate strategies and vision for the department and the group. As a Core Team member on therapeutic projects, you will work with other Core Team members to develop strategies and directions of project teams beyond computational modeling. Furthermore, as a member of the Modeling Group, you will work closely within inter-disciplinary project teams deployed in multiple therapeutic areas. In this critical role you will be responsible for proactively delivering structural and computational expertise to influence efforts in target and lead identification as well as lead optimization.

Essential Functions:

Responsible for leading and executing scientific research for the discovery and development of drug candidates or the research support of marketed drugs. Investigates the feasibility of applying advanced principles and techniques of related scientific specialty to potential inventions, products, and problems. Recommends the development of economical, state-of-the art techniques toward the discovery of therapeutic products. Plans, designs, implements, and analyses computational strategies to advance scientific knowledge of drug substances or techniques to identify such substances. Provides direction to research associates or members of project teams in the initiation and execution of laboratory experimentation, considering economic and safety factors. Works on complex problems where analysis of situations or data requires evaluation of intangible variables, requiring regular use of ingenuity and creativity. Makes contributions to scientific literature and conferences through publication and presentation of research results. Participates in development of patent applications. Acts as a resource and provides work direction for other research personnel.

Knowledge, Experience & Skills:

Essential:

Experience in a broad variety of computational techniques is essential, particularly molecular docking, pharmacophore development, library design and analysis, machine learning methods, and protein-ligand simulation. The ability to analyze chemical structures in relation to biological activity in order to guide novel compound design or help evolve the SAR, both independently and in collaboration with medicinal chemists, is crucial.

Solid knowledge of medicinal chemistry principles, including DMPK, as well as the understanding of IP and its analysis is expected. Excellent leadership and communication skills along with the ability to function as an effective member on multiple project teams are mandatory. The ability to develop tools for use by computational and medicinal chemists would be a great plus.

Typically requires a PhD in an appropriate scientific discipline and 12+ years of relevant experience that demonstrates an expertise in a specific field and sustained excellence in performance and accomplishments that align to company goals. Excellent leadership skills are essential, and direct management experience is desirable. Excellent communication skills (both verbal and technical) and interpersonal skills are required. Must be able to participate in highly effective teams. Exercises independent judgment in developing methods, techniques, and evaluation criteria for obtaining results. Demonstrates ability to recognize anomalous and inconsistent results and interpret experimental outcomes. Maintains in-depth knowledge of state-of-the art principles and theories, applying such knowledge to the research direction that supports Company interests. Demonstrates technical proficiency, scientific creativity, collaboration with others and independent thought in suggesting experimental design and research strategy. Must think critically and creatively and be able to work independently, determine appropriate resources for resolution of problems and have strong organizational and planning skills.

Desirable:

Proficiency with the Schrodinger Software Suite and an aptitude toward creating tools and workflows with Pipeline Pilot will be very useful. Experience in AI/ML is desirable.


The salary range for this position is: $255,425.00 - $330,550.00. Gilead considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary. This position may also be eligible for a discretionary annual bonus, discretionary stock-based long-term incentives (eligibility may vary based on role), paid time off, and a benefits package. Benefits include company-sponsored medical, dental, vision, and life insurance plans*.

For additional benefits information, visit:

https://www.gilead.com/careers/compensation-benefits-and-wellbeing

* Eligible employees may participate in benefit plans, subject to the terms and conditions of the applicable plans.


For jobs in the United States:

As an equal opportunity employer, Gilead Sciences Inc. is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact ApplicantAccommodations@gilead.com for assistance.

For more information about equal employment opportunity protections, please view the 'Know Your Rights' poster.

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Our environment respects individual differences and recognizes each employee as an integral member of our company. Our workforce reflects these values and celebrates the individuals who make up our growing team.

Gilead provides a work environment free of harassment and prohibited conduct. We promote and support individual differences and diversity of thoughts and opinion.


For Current Gilead Employees and Contractors:

Please log onto your Internal Career Site to apply for this job.