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Principal Scientist

Korro Bio

Korro Bio

Cambridge, MA, USA
Posted on Tuesday, June 11, 2024
Korro is a biopharmaceutical company focused on developing a new class of genetic medicines for both rare and highly prevalent diseases using its proprietary RNA editing platform. Korro is generating a portfolio of differentiated programs that are designed to harness the body’s natural RNA editing process to effect a precise yet transient single base edit. By editing RNA instead of DNA, Korro is expanding the reach of genetic medicines by delivering additional precision and tunability, which has the potential for increased specificity and improved long-term tolerability. Using an oligonucleotide-based approach, Korro expects to bring its medicines to patients by leveraging its proprietary platform with precedented delivery modalities, manufacturing know-how, and established regulatory pathways of approved oligonucleotide drugs. Korro’s main therapeutic area is Alpha-1 Antitrypsin Deficiency (AATD). Korro is based in Cambridge, Massachusetts.
We are collaborative and united by a common mission. We are building a company with extraordinary people with an audacious vision to create transformative genetic medicines for prevalent diseases. Our values - Rewrite the future, On the Cutting Edge, Better Together, Dynamically Different, Kindness and Integrity form the fabric of the organization. They are reinforced daily and serve as key dimensions in the hiring process to help us ensure that Korro is a magnet for outstanding talent and a great place to work. Join us as we redefine what's possible in genetic medicine and work to make a lasting impact on human health.
Position Summary:
We are seeking a highly motivated and experienced Principal Scientist to join our Platform team. This lab-based position will focus on driving our understanding of ADAR biology and biochemistry through a variety of biochemical, cellular, and molecular based assays. The candidate will be responsible for leading investigational projects, including design and execution of assays, data analysis/interpretation and presentation to the larger team. The candidate should have demonstrated proficiency in a variety of biochemical, structural, and/or cell-based assays. The candidate will be a motivated team player with a proven ability to mentor and lead junior scientists, have excellent interpersonal and communication skills, and be able to balance multiple high-priority tasks.
Key Responsibilities:
Independently design, execute and troubleshoot various biochemical and cell-based assays to further the company’s understanding of oligo-directed RNA editing including, but not limited to enzyme kinetics, protein purification, protein binding assays (SPR, fluorescence polarization), structural biology, molecular modeling, SHAPEmap and RNA folding, LC-MS, cell-based assays, RNA isolation, Western blotting, qPCR, dPCR and NGS.
Analyze complex data and clearly communicate findings and lead the decision-making process for future scientific projects.
Proactively design and implement new or improved technical solutions to drive the company forward, staying up to date on relevant scientific literature and competitive landscape.
Lead cross-functional teams, applying knowledge and expertise to define project scope and goals while providing mentorship to junior team members.
Seek out, set up, and lead external collaborations and projects with academic labs and CROs.
Required Qualifications:
· PhD with 5+ years of industry experience; MS with 11-16+ years or equivalent industry experience in biochemistry, cell biology or related field[CB1]
· Ability to drive independent and high-level projects forward.
· Ability to learn and implement new techniques and adapt rapidly.
· Excellent attention to detail, time management, and documentation.
· Analyze, report and communicate data rigorously.
· Proven experience in the mentorship and management of research assistants and scientists.
· Ability to multitask and successfully interact with a diverse team of scientists to deliver quality data and results.
Other Knowledge, Experience or Skills recommended:
Experience with oligonucleotide-based therapeutics.
Experience with ADAR biology/biochemistry.
Experience with CryoEM and/or X-ray crystallography.
Candidates who are keen experimentalists, independent thinkers, and enthusiastic team players that have a passion for drug discovery are encouraged to apply.
Benefits: Korro offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance, a dependent care flexible spending account and a Company-funded health savings account and free parking.