We live at a time when bioprocessing has never been more critical. The demand for next-generation vaccines and therapeutics is heavily outweighing the supply – a situation brought upon by the complexities inherent to disease, and to manufacturing these potential solutions. The speed at which biologics can be manufactured cannot keep up with those in development, thus we are perpetually behind the curve of supplying patients with the best therapeutics. Bioprocessing has seemingly reached a stagnation point, or asymptotic behavior comparable to that predicted by Moore’s Law in the electronics industry. And, as the electronics industry has shattered that “law” multiple times, bioprocessing must also prepare for the next quantum leap in order to meet the unrelenting demand. There are fundamental missing links to realizing Industry 4.0 in bioprocessing – truly easy-to-use and reliable sensors, accessible data and analytics, and flexible integration.